Orange Juice

 OJ improves abnormal lipid profiles.

Author/s: Issue: July, 2001

 Three cups of orange juice a day over a 4-week period can significantly increase HDL levels
 and improve a patient's LDL:HDL ratio, suggests this small study of healthy adults with
 moderate hypercholesterolemia. When Canadian investigators asked 25 men and women with
 elevated total and LDL cholesterol and normal triglyceride readings to drink 1, 2, or 3 cups of
 juice a day in three separate 4-week periods, those on the highest dose (750 mL) saw their
 HDL levels increase by 21% and their LDL:HDL ratio decrease by 16%. The researchers also
 observed a 30% increase in plasma triglycerides, but those readings remained in the normal

 Kurowska EM, Spence JD, Jordan J, et al. HDL-cholesterol raising effect of orange juice in
 subjects with hypurcholesferolemia. Am J Clin Ntur. 2000;72:1095-1100.

 COPYRIGHT 2001 A Thomson Healthcare Company
 COPYRIGHT 2001 Gale Group


 Issue: Dec, 2000

 Epidemiologic studies indicate that a high consumption of fruits and vegetables reduces the
 risk of coronary heart disease. It is thought that this benefit may be due to the minor
 components, falvonoids, which have been proposed to inhibit LDL oxidation and platelet
 aggregation as well as to vitamins C, E, and [Beta]-carotene, which act as antioxidants. In
 addition, folic acid and natural folate found in citrus fruit and green vegetables has been
 shown to reduce plasma total homocysteine. Citrus juices, namely orange juice and
 grapefruit juice, are high in flavonoids, folate, and vitamin C, leading them to be potentially
 beneficial in reducing the risk of heart disease. Animal studies have found orange juice to
 promote decreases in cholesterol.

 A study to determine whether orange juice beneficially alters blood lipids in individuals with
 hypercholesterolemia was conducted. Sixteen healthy men and nine healthy women with
 elevated plasma total and LDL-cholesterol levels and normal plasma triacylglycerol
 concentrations served as subjects. Subjects included one, two, or three cups (250 mL each)
 of orange juice into their diets. Each dose was included for a four-week period. After the
 intervention period, subjects took part in a five-week washout period. Plasma lipid, folate,
 homocysteine, and vitamin C concentrations were measured at baseline, after each
 treatment and following the washout period.

 It was found that intake of 750 mL of orange juice per day increased HDL-cholesterol
 concentrations by 21%, triacylglycerol concentrations by 30%, and folate concentrations by
 18%. This amount of orange juice also decreased the LDL-HDL cholesterol ratio by 16% and
 did not impact homocysteine concentrations. There were no significant effects seen with
 less than 750 mL of orange juice daily.

 Three cups of orange juice per day appears to improve blood lipid profiles in individuals with
 hypercholesterolemia. This serves as evidence to the importance of consuming greater than
 five servings of fruits and vegetables each day.

 E. Kurowska, J. Spence, J. Jordan, et al., HDL-Cholesterol-Raising Effect of Orange Juice in
 Subjects With Hypercholesterolemia. Am J Clin Nutr ; 72:1095-1100 (November, 2000)
 [Correspondence: EM Kurowska, Department of Biochemistry, University of Western Ontario,
 London, Ontario, Canada N6A 5C1. E-mail:]

 COPYRIGHT 2000 Technical Insights, a divison of John Wiley & Sons.
 COPYRIGHT 2001 Gale Group